About PREMPRO

PREMPRO is the #1 prescribed combination hormone therapy for menopause.

What is PREMPRO?

PREMPRO is a hormone therapy that contains a combination of estrogens and a progestin. It is a medication your doctor can prescribe to help you manage moderate to severe symptoms of menopause, like hot flashes, night sweats, and vaginal symptoms It is also approved for the prevention of postmenopausal osteoporosis—a form of bone loss that occurs after menopause.

PREMPRO contains estrogens and a progestin and therefore is for women with a uterus who are undergoing natural menopause.

PREMPRO has been an effective treatment option for menopausal symptoms for over 15 years. Women who choose hormone therapy to manage menopausal symptoms should use the lowest effective dose for the shortest duration consistent with treatment goals and risks. PREMPRO comes in several dosage strengths—including two low-dose formulations—that are designed to help you and your physician determine what dose is most appropriate for you.

Is PREMPRO right for me?

Perhaps the first thing to consider before taking PREMPRO is the severity and frequency of your menopausal symptoms. If you’re having disruptive hot flashes or night sweats, then PREMPRO may be an appropriate treatment for you.

It is equally important to review your family history with your healthcare professional prior to beginning therapy with PREMPRO. If there is a family history of heart disease, breast cancer, stroke, blood clots, or osteoporosis, be sure to tell your healthcare professional.

Ask your doctor about PREMPRO at your next visit.

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Important Safety Information

What is the most important information I should know about PREMPRO and PREMPHASE (combinations of estrogens and a progestin)?

Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function)
Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots
Using estrogens with progestins may increase your chance of getting dementia, based on a study of women age 65 years or older
Do not use estrogen-alone to prevent heart disease, heart attacks, or dementia
Using estrogen-alone may increase your chance of getting cancer of the uterus (womb)
Using estrogen-alone may increase your chances of getting strokes or blood clots
Using estrogen-alone may increase your chance of getting dementia, based on a study of women age 65 years or older
You and your healthcare provider should talk regularly about whether you still need treatment with PREMPRO or PREMPHASE

If you use or are considering PREMPRO only to treat your menopausal changes in or around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you.

If you use or are considering PREMPRO only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens would be better for you.

Do not take PREMPRO if you have unusual vaginal bleeding; currently have or have had cancer of the breast or uterus; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; have had a bleeding disorder; are allergic to PREMPRO or any of their ingredients; or think you may be pregnant.

In a clinical trial, the most common side effects (>5%) that occurred with PREMPRO were vaginal bleeding, vaginitis due to yeast or other causes, painful menstruation, breast enlargement, breast pain, and leg cramps.

PREMPRO (conjugated estrogens/medroxyprogesterone acetate tablets) is a prescription treatment used after menopause. PREMPRO is used after menopause to reduce moderate to severe hot flashes, to treat menopausal changes in and around the vagina, and to help reduce your chances of getting osteoporosis (thin, weak bones).

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The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

The product information provided in this site is intended for residents of the United States. The products discussed herein may have different product labeling in different countries.

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