PREMPRO is the #1 prescribed combination hormone therapy for menopause.

What is PREMPRO?

PREMPRO is a hormone therapy that contains a combination of estrogens and a progestin. It is a medication your doctor can prescribe to help you manage moderate to severe symptoms of menopause, like hot flashes, night sweats, and vaginal symptoms. It is also approved for the prevention of postmenopausal osteoporosis—a form of bone loss that occurs after menopause.

PREMPRO contains estrogens and a progestin and therefore is for women with a uterus who are undergoing natural menopause.

PREMPRO has been an effective treatment option for menopausal symptoms for over 15 years. Women who choose hormone therapy to manage menopausal symptoms should use the lowest effective dose for the shortest duration consistent with treatment goals and risks. PREMPRO comes in several dosage strengths—including two low-dose formulations—that are designed to help you and your physician determine what dose is most appropriate for you.

Is PREMPRO right for me?

Perhaps the first thing to consider before taking PREMPRO is the severity and frequency of your menopausal symptoms. If you’re having disruptive hot flashes or night sweats, then PREMPRO may be an appropriate treatment for you.

It is equally important to review your family history with your healthcare professional prior to beginning therapy with PREMPRO. If there is a family history of heart disease, breast cancer, stroke, blood clots, or osteoporosis, be sure to tell your healthcare professional.

Ask your doctor about PREMPRO at your next visit.  Learn more

Scroll for Important Safety Information and Indication

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, strokes or dementia (decline in brain function). Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with PREMPRO.

PREMPRO should not be used if you have unusual vaginal bleeding; have or had cancer; had a stroke or heart attack; have or had blood clots or liver problems; have a bleeding disorder; are allergic to any of its ingredients; or think you may be pregnant.

In a clinical trial, the most common side effects (>5%) that occurred with PREMPRO were vaginal bleeding, vaginitis due to yeast or other causes, painful menstruation, breast enlargement, breast pain, and leg cramps.

INDICATIONS
PREMPRO is used after menopause to reduce moderate to severe hot flashes; to treat moderate to severe dryness, itching, and burning, in and around the vagina; and to help reduce the chances of getting osteoporosis (thin weak bones).

If you are using or are considering using PREMPRO only to treat symptoms of vaginal dryness, consider topical therapies first. If you are using or are considering using PREMPRO only to prevent osteoporosis due to menopause, talk with your health care professional about whether a different treatment or medicine without estrogens might be better for you. PREMPRO should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.


Please see Full Prescribing Information including Boxed Warning and Patient Information.