Glossary

Bilateral oophorectomy

The surgical removal of both ovaries.

Estrogens

A group of female hormones that are responsible for female sexual development and function.

Hot flashes

Temporary episodes of flushing with a sensation of heat.

Hysterectomy

The surgical removal of the uterus.

Natural menopause

Occurs when the ovaries naturally stop their production of the hormones estrogen and progesterone and there are no menstrual periods for 12 consecutive months and no other biological or physiological cause can account for this change.

Night sweats

Hot flashes that occur at night with perspiration.

Ovaries

A pair of female reproductive organs located in the pelvis on each side of the uterus. The ovaries are connected to each other by the Fallopian tubes. Each ovary is about the size and shape of an almond. The ovaries have two functions: they produce eggs (also called ova) and hormones..

Progestin

A synthetic form of progesterone.

Vaginal symptoms

When associated with menopause, vaginal symptoms may include dryness, burning, and itching, and can also contribute to painful intercourse.

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Important Safety Information

What is the most important information I should know about PREMPRO and PREMPHASE (combinations of estrogens and a progestin)?

Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function)
Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots
Using estrogens with progestins may increase your chance of getting dementia, based on a study of women age 65 years or older
Do not use estrogen-alone to prevent heart disease, heart attacks, or dementia
Using estrogen-alone may increase your chance of getting cancer of the uterus (womb)
Using estrogen-alone may increase your chances of getting strokes or blood clots
Using estrogen-alone may increase your chance of getting dementia, based on a study of women age 65 years or older
You and your healthcare provider should talk regularly about whether you still need treatment with PREMPRO or PREMPHASE

If you use or are considering PREMPRO only to treat your menopausal changes in or around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you.

If you use or are considering PREMPRO only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens would be better for you.

Do not take PREMPRO if you have unusual vaginal bleeding; currently have or have had cancer of the breast or uterus; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; have had a bleeding disorder; are allergic to PREMPRO or any of their ingredients; or think you may be pregnant.

In a clinical trial, the most common side effects (>5%) that occurred with PREMPRO were vaginal bleeding, vaginitis due to yeast or other causes, painful menstruation, breast enlargement, breast pain, and leg cramps.

PREMPRO (conjugated estrogens/medroxyprogesterone acetate tablets) is a prescription treatment used after menopause. PREMPRO is used after menopause to reduce moderate to severe hot flashes, to treat menopausal changes in and around the vagina, and to help reduce your chances of getting osteoporosis (thin, weak bones).

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The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

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