Up to 50% of women going through menopause have moderate to severe symptoms within
                        the first few years.

Menopause symptoms

  • Hot Flashes
  • Night Sweats
  • Vaginal Symptoms
As the name suggests, hot flashes are temporary episodes of flushing with a sensation of heat. They can vary in length from less than 1 minute to more than 6 minutes. They may come every hour or only occasionally. And often—but not always—they cause you to sweat. Hot flashes can also bring symptoms that are more complex than just the heat and flushing. Some women may feel irritated, annoyed, or frustrated during a hot flash.

Hot flashes can begin early in menopause and are most common during the first few years after menopause begins. Up to half of all women will experience moderate to severe hot flashes in the first few years of menopause.

For most women, it's easiest to describe the severity of your hot flashes in levels:

  • Mild (sensation of heat without sweating)
  • Moderate (sensation of heat with sweating, able to continue activity)
  • Severe (sensation of heat with sweating, causing cessation of activity)
Night sweats are hot flashes that occur at night and may leave you wet with perspiration. They can interrupt your sleep, which, in turn, may leave you tired or irritable. Up to 42% of women experience moderate to severe night sweats during the first few years of menopause.
Estrogen helps maintain the thickness of the vaginal lining and stimulates vaginal moisture. The decrease in estrogen levels during menopause results in thinning vaginal walls and a decrease in vaginal lubrication. This is called vaginal atrophy. With vaginal atrophy, you may experience dryness, burning, and itching in and around the vagina. And having intercourse may be painful. If these are your only symptoms of menopause, ask your doctor about vaginal estrogen creams.

Relief may be a reality.

Every woman may experience different symptoms of menopause. For some, the symptoms are mild. For others they may be severe enough to become distracting or even unpleasant. It's important to remember that you have options to help you manage them. For women with moderate to severe symptoms who have a uterus, PREMPRO may be one of those options. Talk to your doctor or other healthcare professional about any symptoms you experience and discuss whether PREMPRO may be right for you.

Scroll for Important Safety Information and Indication

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, strokes or dementia (decline in brain function). Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with PREMPRO.

PREMPRO should not be used if you have unusual vaginal bleeding; have or had cancer; had a stroke or heart attack; have or had blood clots or liver problems; have a bleeding disorder; are allergic to any of its ingredients; or think you may be pregnant.

In a clinical trial, the most common side effects (>5%) that occurred with PREMPRO were vaginal bleeding, vaginitis due to yeast or other causes, painful menstruation, breast enlargement, breast pain, and leg cramps.

INDICATIONS
PREMPRO is used after menopause to reduce moderate to severe hot flashes; to treat moderate to severe dryness, itching, and burning, in and around the vagina; and to help reduce the chances of getting osteoporosis (thin weak bones).

If you are using or are considering using PREMPRO only to treat symptoms of vaginal dryness, consider topical therapies first. If you are using or are considering using PREMPRO only to prevent osteoporosis due to menopause, talk with your health care professional about whether a different treatment or medicine without estrogens might be better for you. PREMPRO should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.


Please see Full Prescribing Information including Boxed Warning and Patient Information.